S.H.I.E.L.D. puts together a special team, led by Agent Phil Coulson, to track down a mysterious man with special abilities and the young computer hacker that's encouraging him to reveal himself to the world.
With Colonel Glenn Talbot now on their trail, Coulson and his team seek refuge in the last place anyone would look, where they begin to uncover S.H.I.E.L.D.'S most dangerous secrets -- secrets that could destroy them all.
The team are bewildered by a recent shocking revelation as they face a difficult decision. Meanwhile, Bobbi and Mack declare their loyalty to Hunter; and Ward and Agent 33 take care of a private matter.
War comes to Coulson's doorstep in a way he never anticipated as shocking revelations are brought to light, and Skye struggles to control her new abilities but will soon make a decision that irrevocably changes her life.
As Robert Gonzalez makes his move, Coulson must do whatever it takes to protect the future of S.H.I.E.L.D. Meanwhile Skye's journey to control her powers take a surprising turn when she meets the enigmatic Inhuman named Lincoln.
The story of Melinda May's transformation into "The Cavalry" is revealed as she finds herself at a crossroads in the war between Coulson and Gonzales. As Skye learns more about her true heritage from Lincoln, the truth about Inhumans will send her in a new direction.
A dangerous new alliance is formed as Coulson and Hunter turn to the last person anyone would expect, Grant Ward! As the war between S.H.I.E.L.D. factions continues, Skye and Lincoln will find themselves drawn into this conflict.
S.H.I.E.L.D puts everything on the line to survive a war that blurs the line between friend and foe. Coulson and his team will be forced to make shocking sacrifices that will leave their relationships and their world changed forever.
Director Phil Coulson and Agent Daisy Johnson leading the charge as S.H.I.E.L.D. searches the world for more powered people in the aftermath of their epic battle with Jiaying and her army of Inhumans. However, Coulson and the team soon find out that they are not the only group looking for these new Inhumans.
Having reluctantly agreed to share information with Rosalind and the ATCU, Coulson and the team search for the Inhuman who is killing other Inhumans; May feels that Hunter's mission to take down Ward is getting too personal.
As Daisy and the team try to protect Inhumans, a shocking truth is revealed about S.H.I.E.L.D.'s biggest enemy; with Fitz's help, Simmons recovers information that could get them back through the portal.
Coulson is more determined than ever to get to Gideon Malick and put to an end to Hydra once and for all in the aftermath of his trip to Maveth. Meanwhile, Daisy and the team encounter more Inhumans who have powers like they've never seen before, but will they be friends or enemies of S.H.I.E.L.D?
Agent Daisy Johnson must call upon the Secret Warriors for an inaugural mission that will leave no member unscathed, and S.H.I.E.L.D. learns more about Hive's powers, forcing them to question everyone they trust.
The S.H.I.E.L.D. team is left reeling and decimated as Hive continues to sway Inhumans to his side. But there is a sliver of hope as Agents Fitz and Simmons follow a lead that may be able to stop the maniacal Inhuman once and for all.
In the aftermath of the events of [link=tt3498820], S.H.I.E.L.D feels pressure to reveal their involvement with Inhumans. But with the stakes higher than ever and Hive growing stronger, the team is tested in ways they could never anticipate.
Daisy has left S.H.I.E.L.D. and is trying to solve the mystery of a bunch of serial killings in the Los Angeles area. At the same time her old friends suspect her for the killings and are following her trail in an attempt to find her.
Coulson, Mack and Fitz try to locate and neutralize a rogue group looking to stop Inhuman registration worldwide; Simmons and Dr. Radcliffe have only a short time to save May before she succumbs to her illness.
As Ghost Rider's quest for vengeance brings him into an explosive confrontation with S.H.I.E.L.D., Coulson and Mack must rely on an unlikely ally in their time of desperate need; and Daisy reunites with a familiar face to stop the Watchdogs.