| William Powell | ... | Nick Charles |
| Myrna Loy | ... | Nora Charles |
 | Virginia Grey | ... | Lois MacFay / Linda Mills |
| Otto Kruger | ... | Assistant District Attorney Van Slack |
| C. Aubrey Smith | ... | Colonel Burr MacFay |
| Ruth Hussey | ... | Dorothy Waters, Charles' Nanny |
| Nat Pendleton | ... | Lieutenant Guild |
| Patric Knowles | ... | Dudley Horn, Lois' Fiance |
| Tom Neal | ... | Freddie Coleman, MacFay's Secretary |
| Phyllis Gordon | ... | Mrs. Isabella Bellam, MacFay's Housekeeper |
| Sheldon Leonard | ... | Phil Church |
| Don Costello | ... | 'Diamond Back' Vogel |
| Harry Bellaver | ... | 'Creeps' Binder |
| William A. Poulsen | ... | Nicky Charles Jr. |
| Muriel Hutchison | ... | H. Culverton 'Smitty' Smith |
| Abner Biberman | ... | Dum-Dum, Church's Henchman |
| Marjorie Main | ... | Mrs. Dolley, Landlord Chesterfield Apartments |
| Asta | ... | Himself (dog) |
| rest of cast listed alphabetically: |
| Alexander D'Arcy | ... | Gigolo Who Danced with Nora Charles at West Indies Club (scenes deleted) |
| Murray Alper | ... | Larry, a Father (uncredited) |
| Sandra Andreva | ... | Woman Sitting with Nick in Cafe (uncredited) |
| Roy Barcroft | ... | Slim, a Guard (uncredited) |
| James Blaine | ... | Policeman in Charles' Suite (uncredited) |
| Charles Brokaw | ... | State Trooper (uncredited) |
| Paul E. Burns | ... | Ticket Agent (uncredited) |
| Eddie Buzard | ... | Newsboy (uncredited) |
| Richard Calderon | ... | Raphael, Wacky's Baby (uncredited) |
| Anita Camargo | ... | Hat Check Girl (uncredited) |
| Jack Clifford | ... | Policeman (uncredited) |
| Frank Coletti | ... | State Trooper (uncredited) |
| Nell Craig | ... | Charles' First Nursemaid (uncredited) |
| Carmen D'Antonio | ... | Specialty Dancer (uncredited) |
| Joe Devlin | ... | Barney, MacFay's Bodyguard (uncredited) |
| Joe Downing | ... | Hoodlum (uncredited) |
| Ralph Dunn | ... | Baggage Man (uncredited) |
| Dick Elliott | ... | Detective (uncredited) |
| Matty Fain | ... | Hoodlum Telephoning Nick (uncredited) |
| Walter Fenner | ... | Detective (uncredited) |
| Miguel Fernández Mila | ... | Specialty Dancer (uncredited) |
| Jack Gardner | ... | Driver (uncredited) |
| Edward Gargan | ... | Detective Quinn (uncredited) |
| Martin Garralaga | ... | Pedro, the Informant (uncredited) |
| Eddie Gribbon | ... | Baggage Man (uncredited) |
| Rosemary Grimes | ... | Woman Sitting with Nick in Cafe (uncredited) |
| George Guhl | ... | Second Gate Guard (uncredited) |
| James Guilfoyle | ... | Jake (uncredited) |
| Eddie Hall | ... | Second Baggage Man at Train Station (uncredited) |
| Edward Hearn | ... | Detective (uncredited) |
| Shemp Howard | ... | Wacky (uncredited) |
| Thomas E. Jackson | ... | Detective (uncredited) |
| Gladden James | ... | Fingerprint Man (uncredited) |
| John Kelly | ... | A Father (uncredited) |
| Milton Kibbee | ... | Detective (uncredited) |
| Toni LaRue | ... | Woman Sitting with Nick in Cafe (uncredited) |
| Alphonse Martell | ... | West Indies Club Waiter (uncredited) |
| Pat McKee | ... | A Father (uncredited) |
| Horace McMahon | ... | MacFay's Chauffeur (uncredited) |
| Rudolph Medina | ... | Specialty Dancer (uncredited) |
| Tina Menard | ... | Woman Sitting with Nick in Cafe (uncredited) |
| Howard M. Mitchell | ... | Policeman (uncredited) |
| Frank Moran | ... | Butch, a Father (uncredited) |
| Alberto Morin | ... | West Indies Club Waiter (uncredited) |
| Paul Newlan | ... | Tom--Bodyguard (uncredited) |
| Nellie V. Nichols | ... | Raphael's Mother (uncredited) |
| William Pagan | ... | Policeman (uncredited) |
| Nestor Paiva | ... | West Indies Club Headwaiter (uncredited) |
| Eddie Parker | ... | State Trooper (uncredited) |
| Milton Parsons | ... | Coroner (uncredited) |
| Guy Rett | ... | First Waiter (uncredited) |
| Bert Roach | ... | Cookie, the Drinker (uncredited) |
| Claire Rochelle | ... | Telephone Operator (uncredited) |
| Constantine Romanoff | ... | Tall - ugly father in derby (uncredited) |
| Ramon Ros | ... | Specialty Dancer (uncredited) |
| Charles Sherlock | ... | Police Photographer (uncredited) |
| Lee Shumway | ... | Policeman (uncredited) |
| Rafael Storm | ... | Gigolo Who Danced with Nora Charles at West Indies Club (uncredited) |
| Frank Sully | ... | Pete, a Father (uncredited) |
| William Tannen | ... | State Trooper (uncredited) |
| Stanley Taylor | ... | Taxi Driver (uncredited) |
| Fred Velasco | ... | Specialty Dancer (uncredited) |
| Blanca Vischer | ... | Woman Sitting with Nick in Cafe (uncredited) |
| Doodles Weaver | ... | Gatekeeper, MacFay Estate (uncredited) |
