In the episode "Musso and Frank", David Faustino makes a cameo appearance claiming that Frank had given him detention even though he went to a different school, Polk High. This is the high school his character Bud attends in _"Married... with Children" (1987)_. There is a debate of whether this is actually supposed to actually be Bud or Faustino playing himself.
When the students showed up with signs at a rally to greet a visiting alumnus, one sign read, "Thank you for not watching Hull Hugh." "Hull High" (1990) was NBC's high school show, on opposite this show.
During a rally in one of the episodes, someone had a sign that read "Thank you for not watching "Eerie, Indiana" (1991)" a show that ran in the same time slot on another channel.
Pop-punk band Fall Out Boy released a song titled "Parker Lewis Can't Lose (But I'm Gonna Give It My Best Shot)" on their 2002 debut album "Fall Out Boy's Evening Out With Your Girlfriend."