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Lorenzo's Oil
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  • Lorenzo's actual secretary (Rita Chapman, née Fussey) had an uncredited walk on part in the film.

  • Although a medical drama might seem an odd choice for the director of the "Mad Max" movies, George Miller is in fact a qualified doctor.

  • Michelle Pfeiffer was originally cast as Michaela Odone but dropped out in order to play Catwoman in Batman Returns (1992) a role that Susan Sarandon also expressed interest in. The script for "Lorenzo's Oil" was given to Sarandon but she steadfastly refused to read it until she knew that Pfeiffer was no longer participating in the film.

  • Laura Linney's movie debut.

  • Lorenzo Odone, who doctors had predicted would die in childhood, died Friday May 30, 2008 - one day after his 30th birthday.

  • Don Suddaby (who plays himself in the film) is the actual London biochemist that has synthesized the pure oil (erucic acid) that was used to treat Lorenzo.


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