Continuity: At the end of the movie one of Nick's eyes is blue and one is brown. When they show him again from the side the other eye is blue.
Continuity: When Kaela is using the VR unit to control Flyboy, she uses one hand to flip off Karl, but Flyboy uses the other, even though she is supposed to have complete and exact control over his body.
Plot holes: This ship is supposed to be a medical rescue vessel, yet it only has enough isolation pods (essential to survive the dimension jump) to accommodate the six crew, i.e., no room to transport rescued people.