
| James Belushi | ... | Jim (164 episodes, 2001-2008) |

| Courtney Thorne-Smith | ... | Cheryl (164 episodes, 2001-2008) |

| Kimberly Williams-Paisley | ... | Dana (164 episodes, 2001-2008) |

| Larry Joe Campbell | ... | Andy (164 episodes, 2001-2008) |
 | Taylor Atelian | ... | Ruby (162 episodes, 2001-2008) |

| Billi Bruno | ... | Gracie (161 episodes, 2001-2008) |

| Conner Rayburn | ... | Kyle (83 episodes, 2004-2008) |
 | Garret Sullivan | ... | Kyle (34 episodes, 2002-2004) |
 | Connor Sullivan | ... | Kyle (34 episodes, 2002-2004) |
 | Tony Braunagel | ... | Tony (30 episodes, 2001-2008) |

| Mitch Rouse | ... | Dr. Ryan Gibson / ... (21 episodes, 2004-2007) |
 | John Rubano | ... | John / ... (21 episodes, 2002-2008) |

| Charlie Hartsock | ... | Charlie / ... (16 episodes, 2003-2008) |
 | Anthony Toro | ... | Kyle (11 episodes, 2001-2002) |
 | Brian Toro | ... | Kyle (11 episodes, 2001-2002) |
 | Robert Belushi | ... | Adult Kyle / ... (10 episodes, 2002-2007) |

| Mark Beltzman | ... | Beltzman / ... (9 episodes, 2003-2007) |
 | Willie Amakye | ... | Willie / ... (8 episodes, 2004-2007) |
 | Christopher Moynihan | ... | Chris (8 episodes, 2001-2003) |
 | Jamison Belushi | ... | Little Girl / ... (5 episodes, 2005-2008) |

| Kathleen Noone | ... | Maggie (5 episodes, 2001-2005) |
 | Ted Michaels | ... | Kenny (5 episodes, 2002-2005) |
 | Bruce Jarchow | ... | Dr. Zavranski / ... (5 episodes, 2004-2008) |
 | Siobhan Dunn | ... | Andy's Cousin / ... (4 episodes, 2005-2007) |
 | Carol Pawlak | ... | Angry Parent #2 / ... (4 episodes, 2002-2007) |
 | Max Lesser | ... | Chad / ... (4 episodes, 2005-2006) |

| Cynthia Stevenson | ... | Cindy Devlin (4 episodes, 2003-2007) |

| Tim Bagley | ... | Tim Devlin (4 episodes, 2003-2007) |

| Doug Cameron | ... | Angry Parent #1 / ... (4 episodes, 2002-2006) |

| Robin Krieger | ... | Marilyn Crannis (4 episodes, 2002-2005) |

| Dan Aykroyd | ... | Officer Danny Michalski / ... (4 episodes, 2002-2004) |
 | Ed Lover | ... | Ed (3 episodes, 2001-2002) |

| Tammy Townsend | ... | Ms. Crawford (3 episodes, 2005-2007) |
 | Chris Elliott | ... | Reverend Gaylord Pierson (3 episodes, 2002-2004) |

| Taras Los | ... | Neighbor / ... (3 episodes, 2006-2008) |
 | Brad Paisley | ... | Chad / ... (3 episodes, 2002-2003) |
 | Elizabeth Anne Smith | ... | Sandy (3 episodes, 2002-2003) |

| Jennifer Coolidge | ... | Roxanne (3 episodes, 2003-2004) |

| Laraine Newman | ... | Officer Laraine Elkin / ... (3 episodes, 2003-2004) |

| Michelle Hurd | ... | Kitson (3 episodes, 2004) |

| Maribeth Monroe | ... | Mary Beth / ... (3 episodes, 2007-2008) |

| David Pasquesi | ... | Dave (2 episodes, 2005) |

| Laurel Green | ... | Bernice (2 episodes, 2005-2006) |
 | Soleil Borda | ... | Emma (2 episodes, 2001-2002) |

| Elijah Runcorn | ... | Young Jim (2 episodes, 2006-2007) |

| Jeremy Rowley | ... | Raggedy Ann / ... (2 episodes, 2002-2003) |

| Linda Hamilton | ... | Melissa / ... (2 episodes, 2005) |

| Meagen Fay | ... | Susan / ... (2 episodes, 2007-2008) |
 | Tim Kazurinsky | ... | Elf / ... (2 episodes, 2004) |
 | Andrea Mikolajczak | ... | Mrs. Eggers / ... (2 episodes, 2006-2007) |

| Courtney Taylor Burness | ... | Tabitha (2 episodes, 2007-2008) |
 | James Ward | ... | Dr. Collins / ... (2 episodes, 2007-2008) |
 | Michael Krepack | ... | Ronnie Hart (2 episodes, 2005) |
 | Jesse J. Donnelly | ... | Committee Member / ... (2 episodes, 2006-2007) |
 | Francoise Gralewski | ... | French Florist / ... (2 episodes, 2005-2006) |

| Michael C. McCarthy | ... | Guy #4 / ... (2 episodes, 2005-2006) |
 | Bobby Block | ... | Boy at Party / ... (2 episodes, 2002-2005) |

| Hira Ambrosino | ... | Sarah (2 episodes, 2002-2003) |
 | Glen Clark | ... | Glen (2 episodes, 2002) |
 | Johnny Lee Schell | ... | John (2 episodes, 2002) |
 | Mary Gross | ... | Cynthia Cookson / ... (2 episodes, 2003-2008) |

| Kyle Chavarria | ... | Ashley (2 episodes, 2003-2004) |
 | Andy Morrow | ... | Jason (2 episodes, 2003-2004) |
 | Loren Lazerine | ... | Evan (2 episodes, 2003) |
 | Jill Matson | ... | Patty (2 episodes, 2003) |

| Wayne Newton | ... | Himself (2 episodes, 2003) |

| Lauren Noelle | ... | Showgirl (2 episodes, 2003) |

| Grace Rowe | ... | Police Officer / ... (2 episodes, 2003) |
 | Paul Vinson | ... | Bouncer (2 episodes, 2003) |
 | Andrea Walters | ... | Mrs. Ganzel (2 episodes, 2003) |

| Ingo Rademacher | ... | Ted (2 episodes, 2004) |

| Carla Renata | ... | Sherri (2 episodes, 2004) |
 | Marc Worden | ... | Maitre d' / ... (2 episodes, 2007-2008) |

| Mo Collins | ... | Emily (2 episodes, 2008) |
|
| James Belushi | .... | executive producer (164 episodes, 2001-2008) |
| Warren Bell | .... | executive producer / co-executive producer / ... (67 episodes, 2003-2007) |
| Trevor Kirschner | .... | co-producer (38 episodes, 2003-2007) |
| Suzanne Bukinik | .... | executive producer (36 episodes, 2001-2007) |
| Marc Gurvitz | .... | executive producer (36 episodes, 2001-2007) |
| John D. Beck | .... | co-executive producer / executive producer / ... (36 episodes, 2003-2007) |
| Chris Arrington | .... | associate producer (36 episodes, 2005-2007) |
| Christi Ayo | .... | co-producer (36 episodes, 2005-2007) |
| Ron Hart | .... | co-executive producer / executive producer / ... (35 episodes, 2003-2007) |
| John Peaslee | .... | consulting producer / executive producer / ... (35 episodes, 2005-2007) |
| Judd Pillot | .... | consulting producer / executive producer / ... (35 episodes, 2005-2007) |
| Jesse J. Donnelly | .... | associate producer (34 episodes, 2005-2007) |
| Robert Heath | .... | co-executive producer / supervising producer (32 episodes, 2003-2007) |
| Harry Hannigan | .... | co-producer / producer (32 episodes, 2005-2007) |
| Jonathan Stark | .... | executive producer (28 episodes, 2001-2007) |
| Jana Hunter | .... | co-executive producer (22 episodes, 2004-2006) |
| Mitch Hunter | .... | co-executive producer (22 episodes, 2004-2006) |
| David Feeney | .... | co-executive producer / producer (21 episodes, 2003-2006) |
| Bob Nickman | .... | executive producer / co-executive producer (21 episodes, 2003-2006) |
| Howard J. Morris | .... | executive producer / co-executive producer (20 episodes, 2003-2006) |
| Sylvia Green | .... | co-producer (15 episodes, 2006-2007) |
| Hayes Jackson | .... | co-executive producer (12 episodes, 2007) |
| Nastaran Dibai | .... | co-executive producer / consulting producer (11 episodes, 2001-2003) |
| Jeffrey B. Hodes | .... | co-executive producer / consulting producer (11 episodes, 2001-2003) |
| Myron Lee Nash | .... | associate producer (3 episodes, 2001) |
| Tracy Newman | .... | executive producer (2 episodes, 2001-2003) |
|
| Mark Driscoll | .... | consulting producer (unknown episodes) |
| Jason Fisher | .... | supervising producer (unknown episodes) |
| Tracy Gamble | .... | co-executive producer (unknown episodes) |
| |
|
| Jimmy Brooks | .... | assistant production office coordinator / production staff (45 episodes, 2004-2008) |
| Hayden Ghaffary | .... | script supervisor (40 episodes, 2003-2007) |
| Tracy Newman | .... | consultant / creative consultant (40 episodes, 2004-2007) |
| Christopher J. Nowak | .... | story editor / executive story editor / ... (39 episodes, 2003-2007) |
| Chris Arrington | .... | production coordinator (39 episodes, 2004-2007) |
| Kerry Carter | .... | production assistant / production staff (30 episodes, 2007-2008) |
| Mike Murphy | .... | script coordinator / production staff (29 episodes, 2005-2007) |
| Sylvia Green | .... | executive story editor / story editor (25 episodes, 2004-2006) |
| Regina Naranjo | .... | assistant to executive producer / production staff (22 episodes, 2005-2006) |
| Fay Moss | .... | production staff (19 episodes, 2003-2007) |
| Laura Pierce | .... | production staff (19 episodes, 2003-2007) |
| Chris Poulos | .... | production staff (19 episodes, 2003-2007) |
| Jonah Kuehner | .... | production staff (19 episodes, 2005-2007) |
| Benjamin Davidson | .... | assistant: producer (18 episodes, 2008) |
| Jason Dorris | .... | production assistant (18 episodes, 2008) |
| Lauren Breiting | .... | associate director / technical coordinator (16 episodes, 2003-2007) |
| Lisa Slopey | .... | production staff (16 episodes, 2005-2007) |
| Brian Hilton | .... | production assistant (15 episodes, 2004-2005) |
| Emily Greenspan | .... | production staff (15 episodes, 2005-2007) |
| Robyn Adams | .... | writers' assistant (14 episodes, 2004-2006) |
| Michael P. Fox | .... | production staff (14 episodes, 2004-2006) |
| Neil A. Sheridan | .... | production staff (13 episodes, 2003-2006) |
| Jessica Butler | .... | production staff (13 episodes, 2005-2006) |
| Zak Walshon | .... | assistant to writers / production staff (13 episodes, 2007) |
| Alina Khanjian | .... | production staff (12 episodes, 2005-2006) |
| Bill Beck | .... | assistant to executive producer (12 episodes, 2008) |
| Valerie Lindow | .... | production staff (8 episodes, 2005-2006) |
| Samandhi Alfieri | .... | production staff (8 episodes, 2007) |
| Robinson Green | .... | production staff (8 episodes, 2007) |
| Mara Kelly | .... | production staff (8 episodes, 2007) |
| Sequan Kolibas | .... | production staff (7 episodes, 2007) |
| Harry Hannigan | .... | executive story editor / story editor (6 episodes, 2003-2005) |
| John Schwab | .... | production staff (6 episodes, 2007) |
| Frank Wolff | .... | production staff (6 episodes, 2007) |
| Cindy Appel | .... | production staff (4 episodes, 2003-2005) |
| Christi Ayo | .... | production staff (4 episodes, 2003-2005) |
| Laura Marriott | .... | production staff (3 episodes, 2003-2005) |
| Suniti Warey | .... | production staff (3 episodes, 2003-2005) |
| Terry Mulroy | .... | consultant (3 episodes, 2003-2004) |
| Earl Pomerantz | .... | consultant (3 episodes, 2003-2004) |
| Neely Gurman | .... | production staff (3 episodes, 2004-2005) |
| Kitt Hirasaki | .... | production staff (3 episodes, 2004-2005) |
| Allen Hooper | .... | production staff (3 episodes, 2004-2005) |
| Michael Spear | .... | production staff (3 episodes, 2007) |
| Helen Macdonald | .... | production staff (2 episodes, 2003-2004) |
|
| Charissa Gilmore | .... | publicist (unknown episodes, 2003) |
| Mark J. Greenberg | .... | production executive (unknown episodes, 2003) |
| Nicole Marostica | .... | publicist (unknown episodes, 2003) |
| Phyllis Nelson | .... | production executive (unknown episodes, 2003) |
| Mark Adam Amos | .... | accounting clerk (unknown episodes) |
| Melissa Barbur | .... | production assistant (unknown episodes) |
| Susan Chastain Hulbert | .... | production accountant (unknown episodes) |
| Jeannine Dupuy | .... | script supervisor: "Big Guy" tv spots (unknown episodes) |
| Daniel Egan | .... | production assistant (unknown episodes) |
| Charles Hornsby | .... | assistant to writer (unknown episodes) |
| Max Kisbye | .... | assistant to executive producer (unknown episodes) |
| Chris Lehman | .... | production assistant (unknown episodes) |
| Danai Maraire | .... | production assistant (unknown episodes) |
| Omar McClinton | .... | post-production finance: Touchstone Television (unknown episodes) |
| Jennifer Reed | .... | audience switcher (unknown episodes) |
| Patty Tsilidas | .... | production coordinator (unknown episodes) |
| Kiyana Williams | .... | production assistant (unknown episodes) |
| |