
| Nathan Fillion | ... | Captain Malcolm 'Mal' Reynolds (14 episodes, 2002-2003) |

| Gina Torres | ... | Zoë Washburne (14 episodes, 2002-2003) |

| Alan Tudyk | ... | Hoban 'Wash' Washburne (14 episodes, 2002-2003) |

| Morena Baccarin | ... | Inara Serra (14 episodes, 2002-2003) |

| Adam Baldwin | ... | Jayne Cobb (14 episodes, 2002-2003) |

| Jewel Staite | ... | Kaylee Frye (14 episodes, 2002-2003) |

| Sean Maher | ... | Dr. Simon Tam (14 episodes, 2002-2003) |

| Summer Glau | ... | River Tam (14 episodes, 2002-2003) |
 | Ron Glass | ... | Shepherd Book (14 episodes, 2002-2003) |

| Christina Hendricks | ... | Saffron (2 episodes, 2002-2003) |

| Mark Sheppard | ... | Badger (2 episodes, 2002) |

| Michael Fairman | ... | Adelai Niska (2 episodes, 2002) |

| Jeff Ricketts | ... | Blue Glove Man #1 (2 episodes, 2002) |

| Dennis Cockrum | ... | Blue Glove Man #2 (2 episodes, 2002) |

| Rick Williamson | ... | Bar Guy, Henchman (2 episodes, 2002) |
|
| Mark Cleary | .... | sound effects editor (14 episodes, 2002-2003) |
| Robert Guastini | .... | dialogue editor (14 episodes, 2002-2003) |
| Mike Marchain | .... | supervising adr editor (14 episodes, 2002-2003) |
| Cindy Rabideau | .... | supervising sound editor (14 episodes, 2002-2003) |
| David Yaffe | .... | production sound mixer / production sound designer (14 episodes, 2002-2003) |
| Deb Adair | .... | re-recording mixer (11 episodes, 2002-2003) |
| Bill Jackson | .... | re-recording mixer (11 episodes, 2002-2003) |
| Tom Perry | .... | re-recording mixer (11 episodes, 2002-2003) |
| Devendra Damon Cleary | .... | boom operator (11 episodes, 2002) |
| Kevin McCullough | .... | sound effects editor (10 episodes, 2002-2003) |
| Joe Barnett | .... | re-recording mixer (2 episodes, 2002) |
| Fred Tator | .... | re-recording mixer (2 episodes, 2002) |
| Mathew Waters | .... | re-recording mixer (2 episodes, 2002) |
|
| Susan Cahill | .... | assistant sound editor (unknown episodes) |
| Kevin Hyde | .... | boom operator (unknown episodes) |
| Brian D. Lucas | .... | sound recordist (unknown episodes) |
| Michael Miller | .... | adr mixer (unknown episodes) |
| Steven Morrow | .... | sound mixer: second unit (unknown episodes) |
| |
|
| John J. Gray | .... | assistant: Tim Minear (14 episodes, 2002-2003) |
| Neil Levin | .... | script coordinator (14 episodes, 2002-2003) |
| Stacey Levin | .... | head publicist (14 episodes, 2002-2003) |
| Elyse Allyn Ramsdell | .... | production coordinator (14 episodes, 2002-2003) |
| Jain Sekuler | .... | script supervisor (14 episodes, 2002-2003) |
| Kelly Wheeler | .... | assistant: Gareth Davies (14 episodes, 2002-2003) |
| Michael Boretz | .... | assistant: Joss Whedon (13 episodes, 2002-2003) |
| Cheryl Cain | .... | story editor (13 episodes, 2002-2003) |
| Jenny Lynn | .... | translator: Chinese (13 episodes, 2002-2003) |
| Jose Molina | .... | executive story editor (13 episodes, 2002-2003) |
| James E. Williams | .... | production auditor (13 episodes, 2002-2003) |
| Peter M. Robarts | .... | location manager (12 episodes, 2002-2003) |
| Tony Rudenko | .... | programming: computer graphics / computer graphics programmer (11 episodes, 2002-2003) |
| Anne Fletcher | .... | choreography / choreography by (3 episodes, 2002) |
| Robert Earl Craft | .... | location manager (2 episodes, 2003) |
|
| Ted Bayard | .... | assistant location manager (unknown episodes) |
| Tami Fernholz | .... | payroll accountant (unknown episodes) |
| Ryan Ford | .... | assistant accountant (unknown episodes) |
| Sam Greenmun | .... | spacesuit technician (unknown episodes) |
| Steve Karnes | .... | weapons armorer (unknown episodes) |
| Shaun McNally | .... | production assistant (unknown episodes) |
| Jim Roberts | .... | medic (unknown episodes) |
| Caroline Vandenberg | .... | assistant production coordinator (unknown episodes) |
| |