| James Cromwell | ... | Henry - Roy's Doctor | |
| Justin Kirk | ... | Prior Water / Leatherman in the Park | |
| Al Pacino | ... | Roy Cohn | |
| Mary-Louise Parker | ... | Harper Pitt | |
| Ben Shenkman | ... | Louis Ironson / The Angel of Oceania | |
| Meryl Streep | ... | The Rabbi / Hannah Pitt / Ethel Rosenberg / The Angel of Australia | |
| Emma Thompson | ... | Nurse Emily / Homeless Woman / The Angel of America | |
| Patrick Wilson | ... | Joe Pitt | |
| Jeffrey Wright | ... | Mr. Lies / Belize / The Angel of Europe | |
| John Epperson | ... | Funeral service member (uncredited) | |
| W.A. Walters | ... | Biker (uncredited) |
| Justin Kirk | ... | Prior Water / Leatherman in the Park | |
| Brian Markinson | ... | Martin Heller | |
| Al Pacino | ... | Roy Cohn | |
| Mary-Louise Parker | ... | Harper Pitt | |
| Ben Shenkman | ... | Louis Ironson / The Angel of Oceania | |
| Meryl Streep | ... | The Rabbi / Hannah Pitt / Ethel Rosenberg / The Angel of Australia | |
| Emma Thompson | ... | Nurse Emily / Homeless Woman / The Angel of America | |
| Patrick Wilson | ... | Joe Pitt | |
| Jeffrey Wright | ... | Mr. Lies / Belize / The Angel of Europe | |
| Adonis Kapsalis | ... | Mourner (uncredited) |
| Al Pacino | ... | Roy Cohn | |
| Meryl Streep | ... | The Rabbi / Hannah Pitt / Ethel Rosenberg / The Angel of Australia | |
| Emma Thompson | ... | Nurse Emily / Homeless Woman / The Angel of America | |
| Mary-Louise Parker | ... | Harper Pitt | |
| Justin Kirk | ... | Prior Walter / Leatherman in the Park | |
| Jeffrey Wright | ... | Mr. Lies / Belize / The Angel of Europe | |
| Ben Shenkman | ... | Louis Ironson / The Angel of Oceania | |
| Patrick Wilson | ... | Joe Pitt | |
| Simon Callow | ... | Prior Walter Ancestor #2 | |
| Michael Gambon | ... | Prior Walter Ancestor #1 |
| James Cromwell | ... | Henry - Roy's Doctor | |
| Justin Kirk | ... | Prior Walter / Leatherman in the Park | |
| Al Pacino | ... | Roy Cohn | |
| Mary-Louise Parker | ... | Harper Pitt | |
| Ben Shenkman | ... | Louis Ironson / The Angel of Oceania | |
| Meryl Streep | ... | The Rabbi / Hannah Pitt / Ethel Rosenberg / The Angel of Australia | |
| Emma Thompson | ... | Nurse Emily / Homeless Woman / The Angel of America | |
| Patrick Wilson | ... | Joe Pitt | |
| Jeffrey Wright | ... | Mr. Lies / Belize / The Angel of Europe | |
| Michael Ferreira | ... | Dancer in Church (uncredited) |
| Justin Kirk | ... | Prior Walter / Leatherman in the Park | |
| Al Pacino | ... | Roy Cohn | |
| Mary-Louise Parker | ... | Harper Pitt | |
| Ben Shenkman | ... | Louis Ironson / The Angel of Oceania | |
| Meryl Streep | ... | The Rabbi / Hannah Pitt / Ethel Rosenberg / The Angel of Australia | |
| Emma Thompson | ... | Nurse Emily / Homeless Woman / The Angel of America | |
| Patrick Wilson | ... | Joe Pitt | |
| Jeffrey Wright | ... | Mr. Lies / Belize / The Angel of Europe |
| Justin Kirk | ... | Prior Water / Leatherman in the Park | |
| Anna Orso | ... | Angel | |
| Al Pacino | ... | Roy Cohn | |
| Mary-Louise Parker | ... | Harper Pitt | |
| Ben Shenkman | ... | Louis Ironson / The Angel of Oceania | |
| Meryl Streep | ... | The Rabbi / Hannah Pitt / Ethel Rosenberg / The Angel of Australia | |
| Emma Thompson | ... | Nurse Emily / Homeless Woman / The Angel of America | |
| Patrick Wilson | ... | Joe Pitt | |
| Jeffrey Wright | ... | Mr. Lies / Belize / The Angel of Europe |