The title of the show is essentially meaningless. The comic strip on which the show is based was written by Azuma Kiyohiko, and "Azumanga" is an amalgalm of his name and "manga", the Japanese word for comic books. "Daioh" comes from "Dengeki Daioh" ("Great Electric Shock King"), the monthly Japanese comic anthology in which the comics originally ran.
Tomo's name means "wisdom" in Japanese.
The show was originally broadcast in four-minute segments every weekday on the TV Tokyo satellite channel. Each week's daily segments were reshown as a single 24-minute episode on Saturdays. The Saturday episodes also featured additional footage not screened in the daily segments, including longer opening and closing credits, a preview of the next week's episodes and in some cases a short prologue or epilogue, which accounts for the longer running time than that of the individual segments.
Kimura is the only male character in the main cast.
The clock at Yomi's bedside in Episode 18 has the words "Azuman" and "Daioh" printed on its face.
According to interview done for an art book of the series, the director made a request for the opening song to not have any tone changes or climatic phrases, hence leading to the extremely catchy piece "Soramimi Cake"
According to Osaka in the manga, she was actually born in Wakayama, then raised in Kobe, though Tomo still insists she is "from" Osaka, finding it too confusing to understand.
Episode #21, there was a name Tomoko Kaneda (the voice of Chiyo-chan), amongst staff list of key animators. What drawing she did was never revealed, though it is suspected that it is the depressed Chiyo-chan scribble at the start of the episode
The family names of Yukari and Nyamo are Tanizaki and Kurosawa respectively. Junichiro Tanizaki was one of the major writers of modern Japanese literature, while Akira Kurosawa was a highly respected and extremely influential motion picture director.