Brigitte and Ghost escape from the drug rehab clinic and go to Ghost's grandmother's house to hide out from the werewolf that is trying to mate with Brigitte. The transformation is coming upon her faster and faster, but without a hypodermic needle, she is unable to get the monkshood into her bloodstream. Ghost calls Tyler (Eric Johnson) and asks him to bring them some needles. Tyler injects Brigitte, but she has a strong reaction to the monkshood. Tyler panics and calls Alice (Janet Kidder) at the clinic. When Brigitte next sees Ghost, she is huddled in the attic and claims that Tyler raped her. Angry at Tyler for hurting Ghost, Brigitte asks him to put more gas in the generator. While he is outside, Brigitte locks the door and Tyler is attacked by the werewolf, who has tracked Brigitte down again. Brigitte and Ghost build a trap in the cellar, using the springs of a mattress to hold a variety of spikes, horns, and other sharp objects. They hear a noise and fear the werewolf is breaking into the house, but it's just Alice come to take Ghost back to the clinic. Brigitte notices a sign on the wall that reads, "Don't smoke or I might croak," and realizes that Ghost's grandmother was a nonsmoker and couldn't have been burned from a fire that started because she was smoking in bed, the story that Ghost made up. She confronts Ghost who admits to also making up the story about Tyler raping her. She simply wanted to get rid of him because she was afraid that he was going to take Brigitte away from her.
The werewolf suddenly breaks into the house. Ghost and Alice take refuge in the attic while Brigitte lures the werewolf away. As he is nuzzling her, Brigitte stabs him and then repeatedly bashes him with a curling stone until he goes limp. As Brigitte is checking him to see whether he's dead, he revives and lunges at her. Both of them go tumbling into the cellar. When Alice bends over to look, Ghost bashes her head with a hammer, and Alice tumbles into the cellar, too. Almost completely transformed, Brigitte pleads with Ghost to kill her, but Ghost simply closes the door, locking Brigitte in the cellar. In the final scene, Ghost is in the attic working on a drawing that depicts herself as a fierce warrior with a pet werewolf whom she is going to get to kill everyone she doesn't like, beginning with her grandmother who is soon to be coming home from the hospital.