The 37-day shoot had to cover the scope of Dr. Kinsey's 15 years of research during which he interviewed 18,000 people across the US.
Bill Condon interviewed many of Dr. Kinsey's colleagues before he started writing the script.
This film features Brute Force (Stephen Friedland) uncredited in the background, and just like George Harrison in Life of Brian (1979) he is in there with champagne glass.
In the script, Peter Sarsgaard did not have to strip in the motel scene.
Cole Porter wrote the song "Too Darn Hot" for the Broadway musical "Kiss Me Kate," which premiered in 1948, the same year as the publication of Kinsey's book "Sexual Behavior in the Human Male". The song contains the lyrics "According to the Kinsey report / ev'ry average man you know / much prefers to play his favorite sport / when the temperature is low." The Ella Fitzgerald recording of this song is played on the soundtrack. When MGM produced its movie version, Kiss Me Kate (1953), the same year as the publication of Kinsey's "Sexual Behavior in the Human Female", the film's censors changed the lyrics to "According to the weather report...," a sign of how much more controversial Kinsey's work was after the second book than the first.
During the credits, the producers thank the "University of Indiana" when it is actually "Indiana University" of which Alfred Kinsey was a part. The university notified director Bill Condon of the mistake. Condon gave his word that it would be taken care of when the film went on general release, but the mistake remains.
Bill Condon and Laura Linney appeared at a benefit screening of the movie at Indiana University to help raise money for the Kinsey Institute.
On the DVD commentary, director Bill Condon reveals that he wanted to include in a montage a clip from "I Love Lucy" in which a character makes a joking reference to Dr. Kinsey's research. Condon says that he was unable to use the clip because Lucie Arnaz (the daughter of Lucille Ball and Desi Arnaz) denied him the rights, offering very little explanation aside from claiming that her parents would never allow themselves to be associated with Kinsey.
Laura Linney gained 20 pounds for this film, mainly by eating Krispy Kreme glazed dough nuts.