Grey's Anatomy stars Ellen Pompeo (who has starred in a few movies but was never really noticeable) as the narrator - Meredith Grey. Her mother is the famous surgeon and she is trying to follow in her mother's footsteps. The story revolves around her time as an intern and the people she meets and sort of is portrayed as "survival camp for medical students." The minute she arrives at work, she meets Christina Yang (Sandra Oh - flawless in her bitchy supporting role), George O'Malley (T.R. Knight - one word: breakthrough performer), Izzie Stevens (Katherine Heighl - very, very believable as a model who is more like the girl-next-door), and Alex Karev (Justin Chambers - plays sort of a not-so-likable person). Most of all, there is Dr. Derek Shepherd (Patrick Dempsey - very attractive), the man that Meredith had a one-night stand with - he just happens to be her boss.
This is a show that wants to be liked. It just sort of screams in your face "Love me!" with all its interesting characters who are very different from each other and a nice plot that you just have to be addicted to. The supporting work is clearly a winner. It has a very lovable supporting cast with T.R. Knight as the sweet and sort of the "average guy" as George O'Malley and Katherine Heigl who is very likable in her role - even Sandra Oh is a clear winner on top. And my personal favorite is "the Nazi" - Dr. Miranda Bailey who is played by Chandra Wilson. Very, very well done.
This is sort of a soapy spin on "Scrubs" and "ER" but with light comedy/romance and serious and intense drama where character build up the plot. Some of the characters may get a bit annoying for your taste (ex. Meredith Grey) but the acting is just superb and you can't help liking it. It has a guilty-pleasure feel to it and you just can't help but stay up late for this show. This show is definitely not about "medicine" - when it has to deal with medicine, it has a clear soft side to it. The doctors play heroes (pretty clichéd, but yeah - this IS a hospital show) and save lives or care or has to live up to certain defeat. Just to be aware: This is a show about relationships-within-a-hospital and the life of each person that works there.
The show breaks all the "bad" mid-season shows record. It is just extremely enjoyable. Go check it out - you'll definitely like it if not love it.