- Errors in geography: The face masks in the medicine woman's shelter and the totem poles are not part of Inuit culture. They belong to the Haida Indian tribe who reside much further South down the British Columbia West Coast and the South East area of Alaska in the temperate rain forests.
- Continuity: In the scene when Homer returns to the hotel room, as the screen pans from left to right, Maggie's eyes are noticeably dropped from eye to nose level.
- Continuity: At the start of the movie the church is shown set back from the street (correctly), in later scenes it is shown right by the road, next door to Moe's Tavern.
- Continuity: In the Motel scene many times, you can see that the lock chain slot on the door doesn't have the circle where you put the chain through. It has it in a few shots but than in others it is a straight rectangle.
- Continuity: While giving his report on intermittent blackouts throughout the town Kent Brockman's eyebrows are missing.
- Continuity: When Homer is dressed as General Marriot Suites he's wearing white gloves but after he punches the guard the gloves have vanished.
- Revealing mistakes: When Russ Cargill appears on the dome over Springfield for the first time, watch the crowd on the bottom of the screen. One citizen's hair was not colored in and is transparent.
- Continuity: When they flee the house and jump into the car, the house is on fire, even when Marge runs back into the house to save her and Homer's wedding video, it is on fire. When the townspeople carry the car to the backyard, the house is not on fire.
- Continuity: When the family move to Alaska, the door to their cabin opens to the left (looking at it from the inside) when Homer escapes from Bart and Lisa's "avalanche". But later in the film it opens to the right (from the inside).
- Continuity: When Marge closes the curtain in the motel room the other curtain changes from being open and closed between shots.
- Continuity: When Homer attempts to ride around the metal ball, at first the motorcycle has flames painted on it, and in the next shot the flames are gone, and then show up again.
- Audio/visual unsynchronized: When Green Day's barge begins to sink, they all pull out violins. However, when they start to play, you hear a cello as well.
- Continuity: When Homer dumps the "Pig Crap" silo into Springfield lake, he drives through a load of signs and the concrete fence. When he has dumped the silo and drives away the signs have all gone.
- Continuity: When Homer dumps his silo of pig waste into Lake Springfield, he cuts the ropes with an axe, and dents the side of the car. The dent is gone in all subsequent frames.
- Continuity: When Russ Cargil is speaking to the town of Springfield on the big screen, on the top left hand corner you can see the Simpsons house with the dome turning on an angle cutting half way through the yard, but in other shots it is perfectly straight right at the back of the yard.
- Continuity: Size of the hole atop the dome.
- Continuity: In one scene, Lisa's clipboard is seen from the top with a sheet of paper on it. In the following shot when she snaps it in half, the paper is gone.
- Revealing mistakes: When the crowd of Springfield citizens is searching for Homer, Groundskeeper Willie (who is in the front row) does not have any shading around him while the rest do.
- Continuity: When Bart is looking at Homer trying to eat the fish that he just took out of the lake, all of the other dead fish floating on the surface are gone.
- Continuity: At the beginning of the movie, as Scratchy climbs down the ladder, we can clearly see that he has no tail. However, once he reveals himself, he has a tail.
- Continuity: When Marge and Bart are inside the gas station store while Homer puts gas in the pickup truck, Bart places a buzz cola on the counter next to the beef jerky. When Bart aims his sling-shot to shoot the hot dog off Homers' hand, the buzz cola is now near the tip jar. After he shoots the hot dog, the buzz cola is gone.
- Continuity: During the avalanche scene, Homer is carrying 4 logs, then 3 logs, then 4 logs again.
- Revealing mistakes: Some footprints of Homer's pig start to appear on the ceiling without being created by the pig's hooves.
- Continuity: In the scene with Cargill is in the Oval Office, the portraits change. At first, the pictures are of Ronald Reagan and assumably, Maria Schriver. In the next shot, the portraits have been replaced by a mountain landscape scene.
- Continuity: When Mayor Quimby call Cletus over to check the barrier around Springfield Lake, you can briefly see that Cletus has nothing in his hands, then a second later, he's carrying a possum.
- Continuity: As we see the town's power coming on and off in waves, the camera pans to Mr. Burns Mansion. Mr. Burn's lawn features an exuberant sign reading, "Happy Holidays From Monty Burns." After Mr. Burns releases the hounds on Quimby, Apu, and Dr. Hibert, we see his lawn once more, and the sign is gone.
- Revealing mistakes: When Bart is aiming his slingshot at Homer, you can clearly see there is no stone in it.
- Continuity: When Lisa is visiting the neighborhood’s houses with the petition to stop dumping in Lake Springfield, she comes to Milhouse' house, his lawn is empty but in the next scene there is a large rock in the middle of his lawn.
- Continuity: The Simpsons’ new home in Alaska changes location from: beside the sea next to a mountain to overlooking the sea beside a forest.
- Revealing mistakes: When Homer gets hit by a wreaking ball between ''a rock'' and ''a hard place'' the wreaking ball comes down from the sky and does not seem to be attached to anything.
- Continuity: When Springfield in the dome loses it's power, Chief Wiggam, Dr. Hibbert, and Apu go to Mr. Burns house on the hill which is clearly located outside the dome. How did they get out?
>>> WARNING: Here Be Spoilers <<<
Goofs below here contain information that may give away important plot points. You may not want to read any further if you've not already seen this title.
- Continuity: SPOILER: Just as Homer reaches the top of the dome, the next shot looks up showing the people climbing up on the rope to the hole. You see the top of the dome and the hole, but Homer is nowhere to be seen.
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