Sister named Padmini who married Sunil Srivastav in December of 1992.
Was engaged to actress Tanushree Kaushal. When she couldn't get a good break she moved to the south film industry .
Elder brother named Anand Santoshi . He was born from Pyarelal Santoshi's first marriage. He is 17 years elder than Rajkumar Santoshi. Anand worked as a assistant director and Cheif Sound Recordist at Radiowani.
Was a assistant to director Zafar Hai. Zafar offered Santoshi the chance to direct The Perfect Murder. Santoshi decided it was best not to chase money and write his own script, Ghayal.
Son named Ram and daughter Tanisha.
Wife name is Manila Santoshi.
Was to direct the political thriller film Power in 2012, starring Amitabh Bachchan, Ajay Devgn, Emraan Hashmi, Sanjay Dutt and Anil Kapoor. The film didn't took off as the actors didn't got a suitable date, hence shelved for good.
Directed the shelved film Saamna in 2006 starring Akshay Kumar and Nana Patekar.