Most Popular Female Antagonist Movies and TV Shows
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1. Mean Girls (2004)
PG-13 | 97 min | Comedy
Cady Heron is a hit with The Plastics, the A-list girl clique at her new school, until she makes the mistake of falling for Aaron Samuels, the ex-boyfriend of alpha Plastic Regina George.
Votes: 303,877 | Gross: $86.06M
2. Mary Queen of Scots (2018)
R | 124 min | Biography, Drama, History
Mary Stuart's attempt to overthrow her cousin Elizabeth I, Queen of England, finds her condemned to years of imprisonment before facing execution.
Votes: 25,370 | Gross: $16.47M
3. The Man from U.N.C.L.E. (2015)
PG-13 | 116 min | Action, Adventure, Comedy
In the early 1960s, CIA agent Napoleon Solo and KGB operative Illya Kuryakin participate in a joint mission against a mysterious criminal organization, which is working to proliferate nuclear weapons.
Votes: 242,304 | Gross: $45.45M
4. Mike and Dave Need Wedding Dates (2016)
R | 98 min | Adventure, Comedy, Romance
Two hard-partying brothers place an online ad to find the perfect dates for their sister's Hawaiian wedding. Hoping for a wild getaway, the boys instead find themselves out-hustled by an uncontrollable duo.
Votes: 75,631 | Gross: $46.01M
PG-13 | 122 min | Action, Adventure
In 1957, archaeologist and adventurer Dr. Henry "Indiana" Jones, Jr. (Harrison Ford) is called back into action and becomes entangled in a Soviet plot to uncover the secret behind mysterious artifacts known as the Crystal Skulls.
Votes: 395,344 | Gross: $317.10M
6. Mrs. Doubtfire (1993)
PG-13 | 125 min | Comedy, Drama, Family
After a bitter divorce, an actor disguises himself as a female housekeeper to spend time with his children held in custody by his former wife.
Votes: 222,202 | Gross: $219.20M
7. Misery (1990)
R | 107 min | Drama, Thriller
After a famous author is rescued from a car crash by a fan of his novels, he comes to realize that the care he is receiving is only the beginning of a nightmare of captivity and abuse.
Votes: 165,472 | Gross: $61.28M
8. Dredd (2012)
R | 95 min | Action, Crime, Sci-Fi
In a violent, futuristic city where the police have the authority to act as judge, jury and executioner, a cop teams with a trainee to take down a gang that deals the reality-altering drug, SLO-MO.
Votes: 235,589 | Gross: $13.41M
10. Underworld: Blood Wars (2016)
R | 91 min | Action, Adventure, Fantasy
Vampire death dealer, Selene (Kate Beckinsale) fights to end the eternal war between the Lycan clan and the Vampire faction that betrayed her.
Votes: 63,505 | Gross: $30.35M
12. Bad Teacher (2011)
R | 92 min | Comedy, Romance
A lazy, incompetent middle school teacher who hates her job, her students, and her co-workers is forced to return to teaching to make enough money for breast implants after her wealthy fiancé dumps her.
Votes: 181,996 | Gross: $100.29M
14. Election (1999)
R | 103 min | Comedy, Drama, Romance
A high school teacher's personal life becomes complicated as he works with students during the school elections, particularly with an obsessive overachiever determined to become student body president.
Votes: 83,500 | Gross: $14.88M
16. Addams Family Values (1993)
PG-13 | 94 min | Comedy, Fantasy
The Addams Family try to rescue their beloved uncle Fester from his gold-digging new love, a black widow named Debbie.
Votes: 69,992 | Gross: $48.92M
17. Mirror Mirror (I) (2012)
PG | 106 min | Adventure, Comedy, Drama
An evil queen steals control of a kingdom and an exiled princess enlists the help of seven resourceful rebels to win back her birthright.
Votes: 79,800 | Gross: $64.94M
20. Resident Evil: Retribution (2012)
R | 95 min | Action, Horror, Sci-Fi
Alice fights alongside a resistance movement to regain her freedom from an Umbrella Corporation testing facility.
Votes: 125,740 | Gross: $42.35M
22. The Lair of the White Worm (1988)
R | 93 min | Horror
When an archeologist uncovers a strange skull in foreign land, the residents of a nearby town begin to disappear, leading to further unexplainable occurrences.
Votes: 8,924 | Gross: $1.19M
23. Honeymoon (2014)
R | 87 min | Horror, Mystery, Thriller
A newlywed couple finds their lake-country honeymoon descend into chaos after Paul finds Bea wandering and disoriented in the middle of the night.
Votes: 22,997 | Gross: $0.01M
24. Play Misty for Me (1971)
R | 102 min | Thriller
A brief fling between a male disc jockey and an obsessed female fan takes a frightening, and perhaps even deadly turn when another woman enters the picture.
Votes: 23,260 | Gross: $10.60M
25. Life After Beth (2014)
R | 89 min | Comedy, Fantasy, Horror
A young man's recently deceased girlfriend mysteriously returns from the dead, but he slowly realizes she is not the way he remembered her.
Votes: 18,126 | Gross: $0.08M
27. Silent Night, Deadly Night (1984)
R | 79 min | Horror, Thriller
Little Billy witness his parents getting killed by Santa after being warned by his senile grandpa that Santa punishes those who are naughty. Now Billy is 18, and out of the orphanage, and he has just become Santa, himself.
Votes: 12,122 | Gross: $2.49M
31. Cry Wolf (2005)
PG-13 | 90 min | Drama, Horror, Mystery
Eight unsuspecting high school seniors at a posh boarding school, who delight themselves on playing games of lies, come face-to-face with terror and learn that nobody believes a liar - even when they're telling the truth.
Votes: 25,052 | Gross: $10.05M
32. Teaching Mrs. Tingle (1999)
PG-13 | 96 min | Comedy, Thriller
The story of a girl who is willing to do anything to become Valedictorian, even if it means murdering the teacher that stands in her way.
Votes: 18,916 | Gross: $8.95M
33. Images (1972)
R | 104 min | Drama, Horror, Mystery
Schizophrenic housewife, engulfed by terrorizing apparitions, kills off each, unknowing if these demons are merely figments of her hallucinatory imagination or part of reality.
34. Doghouse (2009)
Not Rated | 89 min | Comedy, Horror, Sci-Fi
A group of men, heading to a remote village to help one of their friends get over his divorce, soon discover that all the women have been infected with a virus that makes them man-hating cannibals.
35. Nina Forever (2015)
R | 98 min | Comedy, Drama, Horror
After his girlfriend Nina dies in a car crash, Rob unsuccessfully attempts suicide. As he begins to overcome his grief, he falls in love with a co-worker, Holly. Their relationship is ... See full summary »
36. Doom (2016 Video Game)
M | Action, Adventure, Horror
On Mars, a massive research facility tapping energy from hell has been overwhelmed by demonic forces. As the last DOOM Marine, you have been resurrected to do one thing; to cleanse this world and send them back to where they came from.
37. Total Frat Movie (2016)
Not Rated | 93 min | Comedy
Three years after getting his fraternity revoked, Charlie and the remaining brothers must throw the greatest rush event to recruit a new pledge class and reinstate their frat.
38. The Shape of Things (2003)
R | 96 min | Comedy, Drama, Romance
A quiet, unassuming man begins to change in a major way as a result of meeting a new, art-student girlfriend, and his friends are unsettled by the transformation.
Votes: 10,531 | Gross: $0.73M
39. The Coed and the Zombie Stoner (2014)
Unrated | 91 min | Comedy, Horror, Romance
When a nerdy sorority girl falls in love with a zombie, it's only a matter of time before a zombie apocalypse is unleashed on campus. The sorority girl discovers that weed is the cure--now ... See full summary »
40. Trash Fire (2016)
R | 91 min | Comedy, Drama, Horror
When Owen is forced to confront the past he's been running from his whole adult life, he and his girlfriend, Isabel, become entangled in a horrifying web of lies, deceit and murder.
41. The Love Factor (1969)
R | 86 min | Comedy, Fantasy, Sci-Fi
A race of topless, large-breasted women from the planet Angvia, in another dimension, come to earth to kidnap women to repopulate their planet.
44. Let's Kill Ward's Wife (2014)
Unrated | 82 min | Comedy, Crime
Ward's wife is a bitch. Everyone knows it. Including Ward. After numerous conversations and ruminations on the subject amongst Ward's colorful group of friends, a fortuitous accident leads ... See full summary »
45. P (2005)
Not Rated | 110 min | Drama, Horror
Whilst growing up in rural Thailand, a young orphan girl is taught the ways of magic by her grandmother. But when grandmother falls sick, Dau is lured to Bangkok to find work so that she ... See full summary »
46. Dr. Jekyll and Ms. Hyde (1995)
PG-13 | 90 min | Comedy, Romance, Sci-Fi
A scientist creating perfumes inherits his great grandfather Dr. Jekyll's formula and decides to use modern technology to improve it. He ends up as an ambitious, ruthless woman. She tries to prevent returning into the spineless man.
Votes: 2,530 | Gross: $2.76M
47. The Legend of Lizzie Borden (1975 TV Movie)
TV-14 | 96 min | Drama, History, Mystery
In Massachusetts in 1893, Lizzie Borden is put on trial for murdering her father and stepmother with an axe.
48. Chastity Bites (2013)
TV-MA | 93 min | Comedy, Horror
In the early 1600's, Countess Elizabeth Bathory slaughtered more than 600 young women, believing if she bathed in the blood of virgins that she would stay young and beautiful forever. Still... See full summary »
49. Strait-Jacket (1964)
Approved | 93 min | Drama, Horror, Thriller
After a twenty-year stay at an asylum for a double murder, a mother returns to her estranged daughter where suspicions arise about her behavior.
50. Farewell, Friend (1968)
PG | 115 min | Action, Adventure, Crime
After an overseas deployment, two former French Foreign Legion members plan to break into the vault of a French corporation.