Cheyenne is escorting a bride and $5000 to his boss. He meets a friend who works now for the railroad who tells Cheyenne a group of young bandits are robbing trains. They strike the train but their goal is more than robbing it.
Arrested and accused of robbery in Lone Butte, Cheyenne escapes to clear his name. The only clues he has are the location of the gang's well-guarded hideout and that the killer was wearing an unusual gold lion's head belt buckle.
Army scout Cheyenne is court-martialed for cowardice when he wants to abandon Army horses the Army needs to raiders who always know where to strike. The post commander is frustrated as is his wife who wants to return back east.
Cheyenne on an Army task is chased by the Sioux. He wounds a miner so he stays to help the miner and his wife. Three men wanted for selling faulty guns to the Sioux arrive with eyes for the wife and the gold although the Sioux threaten.
Cheyenne works for Charley Dolan who is given 24 hours to vacate his property. A gang run by Len Garth is forcing people off their land. He burns the newspaper office killing the owner. Dolan offers money to rebuild the paper.
Cheyenne brings a body into town killed in a strange way. The townspeople suspect Cheyenne is part of a rustler gang. While Cheyenne is hunting for the killer, a girl's jealous boyfriend is hunting Cheyenne thinking he killed his brother.
His gear stolen, Cheyenne follows the thief and killer to a small town. The outlaw has stopped there to see the sheriff - his father. The sheriff resigns so Cheyenne takes the job and falls for a girl who's father was the sheriff.
Cheyenne tries to help a young man with a younger sister and brother and a troubled history. Sadly, Cheyenne who is looking for his friend finds proof that the young man committed a serious crime involving Cheyenne's missing friend.
Cheyenne is given the deed to a livery stable worth $3000 in Gunsight to repay a $1200 debt which sounds like a good deal. Unbeknownst to Cheyenne a $30 weekly protection payment to the Gerrard gang goes along with the stable.
Cheyenne interrupts a stagecoach attack but when it crashes he is left to take care of the lone survivor - a baby. Cheyenne learns that a land grabber murdered to get his claim, then Cheyenne must protect the dead man's heir - the baby.
Looking for a job, Cheyenne rides into town and is caught up in a fight and witnesses a bank holdup. Deputized he goes after the robber, finds him but is conflicted when the fugitive saves him from a bear trap that almost kills him.
Cheyenne is asked to talk to Chief Sitting Bull to calm the waters after his son is accused of killing a miner. A newspaperwoman forces her way onto the trip to interview Chief Sitting Bull and ends up starting an Indian uprising.
A school teacher claims to have killed a bank robber. The townspeople want to celebrate their new hero. It all starts to unravel as his past catches up with him and the people he's lived with want nothing else to do with him.
Cheyenne is called to Washington D.C. to take on a special task for the Army. He is to take the place of married actor/singer/dancer Jim Thornton Merritt who is working with two others to raise money to resurrect the Confederacy.
Cheyenne working for the less than scrupulous Ben Creed as foreman crosses paths with stock owner Thora Flagg who needs help moving her herd to town. She engages Creed in a poker game to win the price to cross his land and Cheyenne.
After Cheyenne takes a cattle herd to Mexico, he is captured by the French. After escaping, he aids a young runaway princess who doesn't like her much older intended husband. He takes her to a rebel camp where they learn her real identity.
A fortune in diamonds awaits anyone who gets to it first. Murder and arson are just some of the ways of keeping some from succeeding. A stranger follows Cheyenne and the treasure hunting party but is he all they have to worry about?
Cheyenne brings a bank robber into town to his old friend Sam. A popular rancher's son is "accidentally" killed by Sam when a drunken mob tries to hang him. It's up to Cheyenne to bring to justice the guilty party and free his friend.
Cheyenne rides into a town looking for a job. He runs into a hired killer he knows who tries to kill him but is shot by the local sheriff. Once he learns who the man was, the sheriff hires Cheyenne to work undercover to find who hired him.
Cheyenne decides to leave a valley engulfed in a ranch war when his boss is bought out. He turns down offers from two other ranches but changes his mind when hands from one leave him to die. He finds love is part of the problem he faces.