Both Lauren Holly and Karen Kopins, who play Betty and Veronica respectively, co-starred in separate theatrical films as Jim Carrey's love interest. Kopins previously played Carrey's girlfriend in Once Bitten (1985), and Holly would go on to co-star in Dumb and Dumber (1994). Holly was also briefly married to Carrey.
There is a line while Archie and Jughead talk about graduating from Riverdale High School, and Jughead says "I wish we never did that". This is a in-joke to the comics, where the gang still attends good old Riverdale High, and have also never aged.