Tupac Shakur was originally cast to play Sharif, but was fired which led to a physical fight with co-Director Allen Hughes. Shakur was charged with assault and battery. Shakur bragged about the altercation on an appearance on Yo! MTV Raps (1988). A tape of the appearance was played at the trial as evidence against Shakur. Shakur was sentenced to fifteen days in jail.
A prison riot scene was cut from the film because it was deemed too intense and would've bumped it up to an NC-17, another reason is because it was complicated for the Hughes brothers since they didn't know how to film and choreograph an action sequence yet.
Larenz Tate grew up on Chicago's Westside, which is controlled by the Vice Lords street gang. At the scene where he enters Cain's grandparents home, he subtly throws up the "5" when shaking Cain's hand.
During the cookout scene, the grocery bags read "Vote Yes on 163. This refers to California Proposition 163, which amended the California Constitution to prohibit the state, or any county, city, or special district, from imposing sales or use taxes on food products used for home consumption.
Tupac Shakur was originally cast to portray the character Sharif in the film, but fell out with the directors (Hughes Brothers) after they fired him due to his disagreement with his character which resulted in a violent altercation between them. However, Shakur appears in the music video from the film "Trigga Gots No Heart" by Spice -1. Shakur is visible in the background of the video with many other "thugs". He is seen twice throughout the video in quick shots. The video was directed by the Hughes Brothers.
During the carjacking scene, Caine's cousin Harold reaches for a stainless Taurus PT99 AFS under the seat of his car. (it was previously mis-identified as the PT92, but the new Blu-Ray screencaps reveal that Harold's gun has the target rear sight of the PT99.)
A-Wax used a two-tone IMI Desert Eagle Mark VII when he, Caine, and O-Dog execute the carjackers at the take-out food stand. It is believed to be the .357 Magnum version, as A-Wax fired ten rounds (nine in the magazine and one in the chamber), but the prop weapon may be chambered in a larger caliber, since he fires ten rounds over the course of three takes (during which it's possible that the gun was reloaded off-camera between the takes).
Clifton Powell, MC Eiht, and Samuel L. Jackson have later voiced major antagonists in the 2004 popular video game Grand Theft Auto: San Andreas, which Menace II Society served as one of it's main inspirations.
The trivia items below may give away important plot points.
A clip in the theatrical trailer featured Stacy and Ronnie talking to either the police or a paramedic. This takes place presumably after Sharif and Caine are killed in the drive-by at the film's end. Anthony is seen crying with his clothes stained in Caine's blood.
The shotgun that O-Dog used during the killing at the take-out place is a Smith & Wesson Model 3000. Although the shotgun has a pistol grip that accepts a folding stock, the stock has been removed. This gun is also used by one of the carjackers.
In the empty classroom scene, Mr. Butler tells Kaine and Sharif "Being a black man in America isn't easy. The hunt is on, and you're the prey. All I'm saying is... All I'm saying is... Survive! All right?" Mr. Butler is played by Charles S. Dutton, who appeared in Surviving the Game (1994), about a group of men who pick up and hunt down a black man in the woods.