Meredith thinks about her loyalties while Alex deals with the fallout of his actions; Amelia and Owen host a dinner party with surprising guests; Jackson makes a suggestion to help April through her recovery.
A familiar face returns to Grey Sloan throwing many of the doctors for a loop. With Catherine putting on the pressure, Bailey has to make a decision about Alex while a tough ER case makes Amelia's bad day even worse.
Richard, Jackson, April and Catherine tackle a grueling trauma case intensified by hospital politics; Amelia finally faces her feelings about Owen; Meredith gets caught between Nathan and Alex over a patient.
The doctors of Grey Sloan encounter a difficult case involving a dangerous patient; Owen receives life-changing news that pushes Amelia to step up to support him; Alex attends a medical conference after making a shocking discovery.