John Malkovich's second time hosting. Amy Poelher returns from maternity leave. Sketches include: A Message from the Secretary of State Designate, John Malkovich Monologue, Gas Right, Shana, Cool Obama, La Rivista Della Televisione, Virgania Horsen's Pony Express, Twins, Weekend Update with Amy Poehler and Seth Meyers, Weekend Update: Plaxico Burress, Weekend Update: David Rasmussen, Weekend Update: Boy George, The Lost Works of Judy Blume, An SNL Digital Short: Jizz in My Pants (featuring Jamie-Lynn Sigler, Molly Sims, Justin Timberlake, and The Lonely Island cameos), J'accuzi. T.I. performs "Whatever You Like" and "Swing Ya Rag".
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References Sesame Street