Totally dependent on her husband, Lokesh, Sanjana feels lonely and neglected and has to bring up two children on her own. Things only get worse when he not only forgets their 10th wedding anniversary but also admits with impunity that he is having an affair with another woman. In order to lure investors from U.K., U.S., and Japan, a businessman, Ravi Anand, hoping to make it big like the Tatas and Birlas, decides to get in physical shape. Arrogant and womanizing college basketball player, Sameer, decides to change to win Divya's heart. In order to wed his sweetheart, Sumitra, and prove himself to his widowed father, Raju leaves home. A football player, Sanjeev Mitra, is inflicted with Cancer and his leg is amputated. These unrelated group of strangers are all fated to face even more challenges when they decide to compete in a 42 kilometer long marathon in Mumbai.