Christian Walker is a cop in special Powers Division for policing super-powered criminals. Walker is an ex-"Power" and yearns for his powers. An unidentified drug kills an old power friend at the same time when Walker loses his partner to another Power. A new partner, a mystery girl and visits to the past of Walker through former friends now enemies Wolfe, who was caught and incarcerated by Walker himself and Johnny who Walker believes to be dead results in a surprisingly intense pilot episode.
After Calista tries to find her powers in a more drastic way, she meets RetroGirl whom Christian knows more about than he's letting on. Meanwhile his partner makes her first official Powers arrest. After a while Christian becomes more suspicious about Johnny Royalle's death, and visits Wolf to seek his help.
As a lethal powers-enhancing drug is unleashed on the public, Detectives Walker and Pilgrim seek out the criminal mastermind behind it with the help of iconic Power, Retro Girl. As clues come to light, Walker considers the possibility that Wolfe, his dangerous former mentor turned nemesis, might have the answers he seeks.
As Retro Girl, Zora and the heroes of the world rush to stop the escape of Wolfe from The Shaft, Walker realizes he must face him alone, the inevitable clash between mentor and disciple that will unravel the deep-seated history between them.
In the wake of the battle to stop Wolfe, the Powers division gathers to mourn the loss of their fellow officers, while Walker seeks answers about his own future and the possibility of becoming Diamond once again. After seeing the uncertain and dangerous side effects of Sway first-hand Johnny Royalle begins unsavory experiments on known subjects of the drug.
After Wolfe pleads to end his life, Walker and Pilgrim must act quickly to stop Johnny Royalle from meeting with Wolfe in The Shaft. Meanwhile Zora struggles with her newfound fame, while Calista becomes more desperate to discover if she truly is a Power.
In order to persuade him to join his new cause to annihilate Wolfe, Royalle reveals to Walker the true nature of Sway and the inevitable devastation it will cause if Wolfe ever escapes. Meanwhile, as the message of Chaotic Chick spreads rapidly with fatal results, it finds its biggest platform yet in a publicity stunt orchestrated for Retro Girl's charitable foundation.
Walker decides how far he is willing to go to regain his powers, as Johnny Royalle sets the plan in motion to kill Wolfe. Meanwhile, the Powers division tries to catch Royalle in the act and discover where Walker's true allegiance lies.