As Masters and Johnson face the press for the first time, they flashback to summer vacation, where Bill is finishing their book, Virginia faces parenting struggles, and Libby is pulling herself out of a depression. Season premiere.
The shock waves surrounding Masters and Johnson's first press conference begin to reverberate around their universe as the book nears its release date. Meanwhile, Masters takes on a powerful, high profile fertility patient with the help of a new doctor in the practice, while Virginia and Libby come to terms with Bill's role in their lives.
Masters and Johnson's book is released and, while reviews are positive, the public's response causes unease around the office. The new spotlight on her mother starts to affect Tessa at school, while Libby does her best to maintain a social life outside of her friendship with Virginia. Meanwhile, Masters and Johnson look to old and new places to capitalize on their burgeoning fame.
Masters consults unexpected advice in convincing Johnson to rededicate herself to the study and to him. A familiar face returns to the clinic for help. Meanwhile, Virginia is distracted by news of Henry and fails to notice Tessa trying to make sense of her home life. Libby confronts the truths of hers as she helps Paul and Joy pick up the pieces of their shattered lives.
Virginia's parents arrive unannounced. Meanwhile, Libby and Masters discover Johnny has been bullied and look to fix it in their own ways. Plus, Johnson finds unexpected excitement in the scent study while Masters, looking to overcome his embarrassing departure from the university, takes on a promising fertility patient that could land him and Johnson back in good graces.
As a result of their spreading celebrity, Masters and Johnson take on a famous couple looking to reinvigorate their sex life. Meanwhile, Tessa learns what childhood with Edna Eshelman must have been like for Virginia. Plus, Masters attempts to connect with Johnny, but misses the mark entirely, and Libby furthers her involvement in Joy's life - with consequences that extend to Paul.
As Johnson jets away to Las Vegas with Dan Logan, Masters uses her absence to begin his surrogacy program. Meanwhile, Libby comes to terms with her current and past relationships. And Barton considers starting one of his own.
Libby tries to mask her feelings by setting Paul up with a friend. Meanwhile, Masters continues his surrogacy program, now under the critical eye of Johnson. And Lester volunteers as their first male surrogate.
Johnson objects to Masters' program after both Nora and Lester have missteps in the protocol. Meanwhile, as Libby's birthday approaches the men in her life are aiming to please. Plus, Tessa explores what sex really means to her.
Masters, Johnson, Logan and his wife gather in New York for a dinner in which agendas collide, truths are exposed and no relationship emerges unscathed. Back home, Libby faces an accusation that threatens her family's foundation.
On the heels of their disastrous dinner in New York, Masters and Johnson return to find their life's work in jeopardy while under the scrutiny of the press and their publisher in preparation for their new book.