In the movie the character who plays the immaculately dressed blonde female AA member of the group is in real life a singer called Kim Gordon. She was the lead singer of the legendary punk rock band Sonic Youth, whose music was an inspiration for another legendary rock band called Nirvana.
In the movie Jonah Hill's character has to take a trip to New York, where he will meet Andy Warhol. In the movie, one of the AA group members is actor Udo Kier, who in real life performed in one of Andy Warhols movies, called Blood for Dracula.
Art imitating life: this movies' plot evolves around a drunk who gets into a car wreck. Joaquin Phoenix has experienced alcohol addiction and a car accident in real life as well. 1 year after he went into rehab, on January 26, 2006, Phoenix was in a car accident on a winding canyon road that overturned his car. The cause was due to a brake failure though and not due to drunk driving.