Reynolds begins to build his department as Dr. Sharpe battles skepticism from a patient's parents. Meanwhile, Max helps Bloom find a solution for a pregnant patient in a tough spot, all the while continuing to avoid the reality of his diagnosis.
When Max volunteers New Amsterdam to take over for a short-staffed hospital nearby, things get chaotic quickly. Iggy has a crisis of conscience after receiving the news that funding for a garden has been granted and an eager resident learns a secret about Dr. Bloom.
A journalist visits New Amsterdam to shadow Max and learn about the hospital. Bloom and Reynolds have a major disagreement after she makes a call against protocol and Kapoor deals with issues from his past.
The pressure is on as Max takes on his first annual fundraising gala at the hospital and emotions are high as some of the doctor's families join them for the event. Iggy struggles to break difficult news to his daughter and Bloom and Reynolds continue to deal with the fallout of their argument. Meanwhile, Kapoor and Dr. Sharpe work together to find out what is making a father and son duo so sick.
With a big domino transplant procedure on the line, Max must decide if he can be present in the hospital while also dealing with his illness. Meanwhile, a bond with a patient makes Bloom consider her personal life and Iggy makes progress on a long-standing case.
A patient's treatment plan takes an unexpected turn when Max gets overly invested. Meanwhile, Reynolds celebrates his birthday with some help from the hospital and Kapoor grapples with a case that hits close to home.
Max convinces Dr. Sharpe to take a risk on his course of treatment and Bloom grapples with a difficult conversation. Meanwhile, Dr. Kapoor considers helping his son in a big way after some advice from a friend.
As Max fights for his life, New Amsterdam is in full swing with a pertinent heart surgery that is not covered by insurance and a potential nurses walk out. Sharpe must finally come clean about Max's condition.
Reynolds confronts a difficult episode from his past. Max distracts himself from chemotherapy by taking on the case of a frequent-flyer patient. Frome helps a young man suffering from severe delusions. Sharpe worries about Bloom's attempt to detox.
Max (Ryan Eggold) continues to work to solve underlying problems within the hospital despite his continuing struggles with treatment. Meanwhile, Reynolds (Jocko Sims) makes the choice to do a costly surgery to determine an elusive diagnosis and Bloom (Janet Montgomery) must face her personal demons head-on.
Max bonds with the patients undergoing chemo with him, but a conversation leads him to struggle with his reality. Meanwhile, Reynolds has difficulty handling a personal matter regarding a patient's family and Iggy struggles with a realization regarding his daughter.
When a history-making blizzard hits New York, Max and his staff must work together to keep the patients safe with few resources, even if it means taking to the streets of the city and braving the storm.
As the doctors continue to weather the storm without power, Max relies on an unlikely source to get the lights back on. Reynolds must get creative as he continues to work to save Hugh with very few resources.
Reynolds struggles to help a young cystic fibrosis patient with curious symptoms. Kapoor finally comes face-to-face with Ella after their awkward encounter. Sharpe takes a major step in her personal life.
Max goes head-to-head with hospital administration when he comes up with a new plan for patients without insurance. Iggy struggles with an accusation brought against him. Sharpe navigates her role as deputy medical director.