Prince of Peoria is based in a real city located in central Illinois. Cut scenes in the show capture views of downtown Peoria and shots of the skyline from the Illinois River. Peoria is the 7th largest city in Illinois with a population of around 113,000.
The trivia item below may give away important plot points.
In the episode "Best. Holiday. Ever." Regina was afraid of spiders. Cynthia K. McWilliams is actually arachnophobia. When the Queen Spider comes to her ankles, Cynthia was really uncomfortable. She is not a huge dog fan either.